Endocrine Abstracts

During the metaphase to anaphase transition of mitosis, destruction of the human securin, pituitary tumor-transforming gene (PTTG), and subsequent activation of the cysteine endopeptidase separase, leads to the cleavage of RAD21, a component protein of the cohesin complex. The developing fetal brain has rapidly proliferating neuronal cells, whilst adult neurons no longer proliferate and are maintained in G0 status of the cell cycle. We have previously investigated the expressi...